About Transcription termination factor 1, mitochondrial
Transcription termination factor 1, mitochondrial (MTERF1) is a protein
from Homo sapiens identified by UniProt accession
Q99551, 399 residues long.
MolForge cross-references it against 0 known binders and
37 disease associations.
Target properties
| Protein name | Transcription termination factor 1, mitochondrial |
|---|
| UniProt accession | Q99551 |
|---|
| Gene | MTERF1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 399 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (37)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.30
- hemoglobin measurement · score 0.22
- smoking status measurement · score 0.20
- hair color · score 0.14
- hair colour measurement · score 0.14
- erythrocyte count · score 0.12
- mean corpuscular hemoglobin concentration · score 0.07
- red blood cell density measurement · score 0.06
- neoplasm · score 0.05
- breast carcinoma · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99551-F1 | alphafold | PREDICTED | 84.94 | — |
Amino-acid sequence (399 residues)
MQSLSLGQTS ISKGLNYLTI MAPGNLWHMR NNFLFGSRCW MTRFSAENIF KSVSFRLFGV KCHNTDSEPL KNEDLLKNLL TMGVDIDMAR KRQPGVFHRM ITNEQDLKMF LLSKGASKEV IASIISRYPR AITRTPENLS KRWDLWRKIV TSDLEIVNIL ERSPESFFRS NNNLNLENNI KFLYSVGLTR KCLCRLLTNA PRTFSNSLDL NKQMVEFLQA AGLSLGHNDP ADFVRKIIFK NPFILIQSTK RVKANIEFLR STFNLNSEEL LVLICGPGAE ILDLSNDYAR RSYANIKEKL FSLGCTEEEV QKFVLSYPDV IFLAEKKFND KIDCLMEENI SISQIIENPR VLDSSISTLK SRIKELVNAG CNLSTLNITL LSWSKKRYEA KLKKLSRFA
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