About P2X purinoceptor 4
P2X purinoceptor 4 (P2RX4) is a protein
from Homo sapiens identified by UniProt accession
Q99571, 388 residues long.
MolForge cross-references it against 0 known binders and
255 disease associations.
Target properties
| Protein name | P2X purinoceptor 4 |
|---|
| UniProt accession | Q99571 |
|---|
| Gene | P2RX4 |
|---|
| Organism | Homo sapiens |
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| Length | 388 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (255)
Diseases linked to this target (Open Targets).
- body mass index · score 0.35
- C-reactive protein measurement · score 0.25
- type 2 diabetes mellitus · score 0.13
- serum alanine aminotransferase measurement · score 0.13
- cutaneous melanoma · score 0.10
- experimental autoimmune encephalomyelitis · score 0.08
- axial length measurement · score 0.08
- cancer · score 0.07
- colitis · score 0.07
- schizophrenia · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99571-F1 | alphafold | PREDICTED | 89.27 | — |
Amino-acid sequence (388 residues)
MAGCCAALAA FLFEYDTPRI VLIRSRKVGL MNRAVQLLIL AYVIGWVFVW EKGYQETDSV VSSVTTKVKG VAVTNTSKLG FRIWDVADYV IPAQEENSLF VMTNVILTMN QTQGLCPEIP DATTVCKSDA SCTAGSAGTH SNGVSTGRCV AFNGSVKTCE VAAWCPVEDD THVPQPAFLK AAENFTLLVK NNIWYPKFNF SKRNILPNIT TTYLKSCIYD AKTDPFCPIF RLGKIVENAG HSFQDMAVEG GIMGIQVNWD CNLDRAASLC LPRYSFRRLD TRDVEHNVSP GYNFRFAKYY RDLAGNEQRT LIKAYGIRFD IIVFGKAGKF DIIPTMINIG SGLALLGMAT VLCDIIVLYC MKKRLYYREK KYKYVEDYEQ GLASELDQ
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