Neuroserpin (SERPINI1)

About Neuroserpin

Neuroserpin (SERPINI1) is a protein from Homo sapiens identified by UniProt accession Q99574, 410 residues long. MolForge cross-references it against 0 known binders and 103 disease associations.

Target properties

Protein name	Neuroserpin
UniProt accession	Q99574
Gene	SERPINI1
Organism	Homo sapiens
Length	410 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (103)

Diseases linked to this target (Open Targets).

familial encephalopathy with neuroserpin inclusion bodies · score 0.67
progressive myoclonus epilepsy · score 0.37
hair colour measurement · score 0.30
skin pigmentation measurement · score 0.30
eye colour measurement · score 0.30
blood pressure · score 0.27
Abnormality of the nervous system · score 0.27
protein measurement · score 0.26
platelet count · score 0.24
hypertension · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99574-F1	alphafold	PREDICTED	88.11	—

Amino-acid sequence (410 residues)

MAFLGLFSLL VLQSMATGAT FPEEAIADLS VNMYNRLRAT GEDENILFSP LSIALAMGMM ELGAQGSTQK EIRHSMGYDS LKNGEEFSFL KEFSNMVTAK ESQYVMKIAN SLFVQNGFHV NEEFLQMMKK YFNAAVNHVD FSQNVAVANY INKWVENNTN NLVKDLVSPR DFDAATYLAL INAVYFKGNW KSQFRPENTR TFSFTKDDES EVQIPMMYQQ GEFYYGEFSD GSNEAGGIYQ VLEIPYEGDE ISMMLVLSRQ EVPLATLEPL VKAQLVEEWA NSVKKQKVEV YLPRFTVEQE IDLKDVLKAL GITEIFIKDA NLTGLSDNKE IFLSKAIHKS FLEVNEEGSE AAAVSGMIAI SRMAVLYPQV IVDHPFFFLI RNRRTGTILF MGRVMHPETM NTSGHDFEEL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards