About GTP-binding protein Rit2
GTP-binding protein Rit2 (RIT2) is a protein
from Homo sapiens identified by UniProt accession
Q99578, 217 residues long.
MolForge cross-references it against 0 known binders and
94 disease associations.
Target properties
| Protein name | GTP-binding protein Rit2 |
|---|
| UniProt accession | Q99578 |
|---|
| Gene | RIT2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 217 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (94)
Diseases linked to this target (Open Targets).
- Parkinson disease · score 0.50
- body mass index · score 0.45
- adolescent idiopathic scoliosis · score 0.39
- body fat percentage · score 0.38
- body weight · score 0.38
- FEV/FVC ratio · score 0.36
- lean body mass · score 0.35
- physical activity measurement · score 0.34
- fat body mass · score 0.34
- high density lipoprotein cholesterol measurement · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99578-F1 | alphafold | PREDICTED | 87.84 | — |
Amino-acid sequence (217 residues)
MEVENEASCS PGSASGGSRE YKVVMLGAGG VGKSAMTMQF ISHQFPDYHD PTIEDAYKTQ VRIDNEPAYL DILDTAGQAE FTAMREQYMR GGEGFIICYS VTDRQSFQEA AKFKELIFQV RHTYEIPLVL VGNKIDLEQF RQVSTEEGLS LAQEYNCGFF ETSAALRFCI DDAFHGLVRE IRKKESMPSL MEKKLKRKDS LWKKLKGSLK KKRENMT
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