About Zinc finger and BTB domain-containing protein 18
Zinc finger and BTB domain-containing protein 18 (ZBTB18) is a protein
from Homo sapiens identified by UniProt accession
Q99592, 522 residues long.
MolForge cross-references it against 0 known binders and
75 disease associations.
Target properties
| Protein name | Zinc finger and BTB domain-containing protein 18 |
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| UniProt accession | Q99592 |
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| Gene | ZBTB18 |
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| Organism | Homo sapiens |
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| Length | 522 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (75)
Diseases linked to this target (Open Targets).
- Intellectual disability · score 0.62
- intellectual disability, autosomal dominant · score 0.55
- genetic disorder · score 0.51
- neurodegenerative disease · score 0.49
- body height · score 0.39
- Global developmental delay · score 0.37
- complex neurodevelopmental disorder · score 0.37
- protein measurement · score 0.35
- Neurodevelopmental delay · score 0.34
- response to allogeneic hematopoietic stem cell transplant · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99592-F1 | alphafold | PREDICTED | 51.68 | — |
Amino-acid sequence (522 residues)
MEFPDHSRHL LQCLSEQRHQ GFLCDCTVLV GDAQFRAHRA VLASCSMYFH LFYKDQLDKR DIVHLNSDIV TAPAFALLLE FMYEGKLQFK DLPIEDVLAA ASYLHMYDIV KVCKKKLKEK ATTEADSTKK EEDASSCSDK VESLSDGSSH IAGDLPSDED EGEDEKLNIL PSKRDLAAEP GNMWMRLPSD SAGIPQAGGE AEPHATAAGK TVASPCSSTE SLSQRSVTSV RDSADVDCVL DLSVKSSLSG VENLNSSYFS SQDVLRSNLV QVKVEKEASC DESDVGTNDY DMEHSTVKES VSTNNRVQYE PAHLAPLRED SVLRELDRED KASDDEMMTP ESERVQVEGG MESSLLPYVS NILSPAGQIF MCPLCNKVFP SPHILQIHLS THFREQDGIR SKPAADVNVP TCSLCGKTFS CMYTLKRHER THSGEKPYTC TQCGKSFQYS HNLSRHAVVH TREKPHACKW CERRFTQSGD LYRHIRKFHC ELVNSLSVKS EALSLPTVRD WTLEDSSQEL WK
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