T-box transcription factor TBX5 (TBX5)

About T-box transcription factor TBX5

T-box transcription factor TBX5 (TBX5) is a protein from Homo sapiens identified by UniProt accession Q99593, 518 residues long. MolForge cross-references it against 0 known binders and 406 disease associations.

Target properties

Protein name	T-box transcription factor TBX5
UniProt accession	Q99593
Gene	TBX5
Organism	Homo sapiens
Length	518 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (406)

Diseases linked to this target (Open Targets).

Holt-Oram syndrome · score 0.83
heart rate · score 0.61
familial bicuspid aortic valve · score 0.55
atrial fibrillation · score 0.52
Abnormality of the cardiovascular system · score 0.51
electrocardiography · score 0.51
congenital heart disease · score 0.47
QRS duration · score 0.47
PR interval · score 0.46
neurodegenerative disease · score 0.46

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99593-F1	alphafold	PREDICTED	62.64	—

Amino-acid sequence (518 residues)

MADADEGFGL AHTPLEPDAK DLPCDSKPES ALGAPSKSPS SPQAAFTQQG MEGIKVFLHE RELWLKFHEV GTEMIITKAG RRMFPSYKVK VTGLNPKTKY ILLMDIVPAD DHRYKFADNK WSVTGKAEPA MPGRLYVHPD SPATGAHWMR QLVSFQKLKL TNNHLDPFGH IILNSMHKYQ PRLHIVKADE NNGFGSKNTA FCTHVFPETA FIAVTSYQNH KITQLKIENN PFAKGFRGSD DMELHRMSRM QSKEYPVVPR STVRQKVASN HSPFSSESRA LSTSSNLGSQ YQCENGVSGP SQDLLPPPNP YPLPQEHSQI YHCTKRKEEE CSTTDHPYKK PYMETSPSEE DSFYRSSYPQ QQGLGASYRT ESAQRQACMY ASSAPPSEPV PSLEDISCNT WPSMPSYSSC TVTTVQPMDR LPYQHFSAHF TSGPLVPRLA GMANHGSPQL GEGMFQHQTS VAHQPVVRQC GPQTGLQSPG TLQPPEFLYS HGVPRTLSPH QYHSVHGVGM VPEWSDNS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards