About ETS-related transcription factor Elf-4
ETS-related transcription factor Elf-4 (ELF4) is a protein
from Homo sapiens identified by UniProt accession
Q99607, 663 residues long.
MolForge cross-references it against 0 known binders and
279 disease associations.
Target properties
| Protein name | ETS-related transcription factor Elf-4 |
|---|
| UniProt accession | Q99607 |
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| Gene | ELF4 |
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| Organism | Homo sapiens |
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| Length | 663 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (279)
Diseases linked to this target (Open Targets).
- autoinflammatory syndrome, familial, X-linked, Behcet-like 2 · score 0.56
- neurodegenerative disease · score 0.50
- inflammatory bowel disease · score 0.38
- ulcer disease · score 0.37
- skin basal cell carcinoma · score 0.37
- gliomatosis cerebri · score 0.37
- Endometrial Endometrioid Adenocarcinoma · score 0.37
- breast ductal adenocarcinoma · score 0.37
- Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation · score 0.37
- Fever · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99607-F1 | alphafold | PREDICTED | 48.68 | — |
Amino-acid sequence (663 residues)
MAITLQPSDL IFEFASNGMD DDIHQLEDPS VFPAVIVEQV PYPDLLHLYS GLELDDVHNG IITDGTLCMT QDQILEGSFL LTDDNEATSH TMSTAEVLLN MESPSDILDE KQIFSTSEML PDSDPAPAVT LPNYLFPASE PDALNRAGDT SDQEGHSLEE KASREESAKK TGKSKKRIRK TKGNRSTSPV TDPSIPIRKK SKDGKGSTIY LWEFLLALLQ DRNTCPKYIK WTQREKGIFK LVDSKAVSKL WGKQKNKPDM NYETMGRALR YYYQRGILAK VEGQRLVYQF KEMPKDLVVI EDEDESSEAT AAPPQASTAS VASASTTRRT SSRVSSRSAP QGKGSSSWEK PKIQHVGLQP SASLELGPSL DEEIPTTSTM LVSPAEGQVK LTKAVSASSV PSNIHLGVAP VGSGSALTLQ TIPLTTVLTN GPPASTTAPT QLVLQSVPAA STFKDTFTLQ ASFPLNASFQ DSQVAAPGAP LILSGLPQLL AGANRPTNPA PPTVTGAGPA GPSSQPPGTV IAAFIRTSGT TAAPRVKEGP LRSSSYVQGM VTGAPMEGLL VPEETLRELL RDQAHLQPLP TQVVSRGSHN PSLLGNQTLS PPSRPTVGLT PVAELELSSG SGSLLMAEPS VTTSGSLLTR SPTPAPFSPF NPTSLIKMEP HDI
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