Tetratricopeptide repeat protein 1 (TTC1)

About Tetratricopeptide repeat protein 1

Tetratricopeptide repeat protein 1 (TTC1) is a protein from Homo sapiens identified by UniProt accession Q99614, 292 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.

Target properties

Protein name	Tetratricopeptide repeat protein 1
UniProt accession	Q99614
Gene	TTC1
Organism	Homo sapiens
Length	292 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (30)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
FEV/FVC ratio · score 0.30
Abnormal brain morphology · score 0.27
mean platelet volume · score 0.22
lean body mass · score 0.20
base metabolic rate measurement · score 0.13
body weight · score 0.12
erythrocyte count · score 0.09
mean corpuscular hemoglobin concentration · score 0.09
body mass index · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99614-F1	alphafold	PREDICTED	77.42	—

Amino-acid sequence (292 residues)

MGEKSENCGV PEDLLNGLKV TDTQEAECAG PPVPDPKNQH SQSKLLRDDE AHLQEDQGEE ECFHDCSASF EEEPGADKVE NKSNEDVNSS ELDEEYLIEL EKNMSDEEKQ KRREESTRLK EEGNEQFKKG DYIEAESSYS RALEMCPSCF QKERSILFSN RAAARMKQDK KEMAINDCSK AIQLNPSYIR AILRRAELYE KTDKLDEALE DYKSILEKDP SIHQAREACM RLPKQIEERN ERLKEEMLGK LKDLGNLVLR PFGLSTENFQ IKQDSSTGSY SINFVQNPNN NR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards