DnaJ homolog subfamily C member 7 (DNAJC7)

About DnaJ homolog subfamily C member 7

DnaJ homolog subfamily C member 7 (DNAJC7) is a protein from Homo sapiens identified by UniProt accession Q99615, 494 residues long. MolForge cross-references it against 0 known binders and 79 disease associations.

Target properties

Protein name	DnaJ homolog subfamily C member 7
UniProt accession	Q99615
Gene	DNAJC7
Organism	Homo sapiens
Length	494 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (79)

Diseases linked to this target (Open Targets).

amyotrophic lateral sclerosis · score 0.40
Amyotrophic lateral sclerosis · score 0.37
breast adenocarcinoma · score 0.18
low grade glioma · score 0.17
epilepsy · score 0.12
Neurodevelopmental delay · score 0.12
Blackfan-Diamond anemia · score 0.07
non-alcoholic fatty liver disease · score 0.06
hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.06
hemoglobin D disease · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99615-F1	alphafold	PREDICTED	90.31	—

Amino-acid sequence (494 residues)

MAAAAECDVV MAATEPELLD DQEAKREAET FKEQGNAYYA KKDYNEAYNY YTKAIDMCPK NASYYGNRAA TLMMLGRFRE ALGDAQQSVR LDDSFVRGHL REGKCHLSLG NAMAACRSFQ RALELDHKNA QAQQEFKNAN AVMEYEKIAE TDFEKRDFRK VVFCMDRALE FAPACHRFKI LKAECLAMLG RYPEAQSVAS DILRMDSTNA DALYVRGLCL YYEDCIEKAV QFFVQALRMA PDHEKACIAC RNAKALKAKK EDGNKAFKEG NYKLAYELYT EALGIDPNNI KTNAKLYCNR GTVNSKLRKL DDAIEDCTNA VKLDDTYIKA YLRRAQCYMD TEQYEEAVRD YEKVYQTEKT KEHKQLLKNA QLELKKSKRK DYYKILGVDK NASEDEIKKA YRKRALMHHP DRHSGASAEV QKEEEKKFKE VGEAFTILSD PKKKTRYDSG QDLDEEGMNM GDFDPNNIFK AFFGGPGGFS FEASGPGNFF FQFG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards