Cell division cycle-associated protein 3 (CDCA3)

About Cell division cycle-associated protein 3

Cell division cycle-associated protein 3 (CDCA3) is a protein from Homo sapiens identified by UniProt accession Q99618, 268 residues long. MolForge cross-references it against 0 known binders and 135 disease associations.

Target properties

Protein name	Cell division cycle-associated protein 3
UniProt accession	Q99618
Gene	CDCA3
Organism	Homo sapiens
Length	268 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (135)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.45
congenital stationary night blindness 1H · score 0.33
genetic disorder · score 0.18
Abnormality of refraction · score 0.17
Myopia · score 0.13
refractive error · score 0.12
retinal vasculature measurement · score 0.11
age at onset · score 0.11
refractive error measurement · score 0.11
hepatocellular carcinoma · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99618-F1	alphafold	PREDICTED	58.80	—

Amino-acid sequence (268 residues)

MGSAKSVPVT PARPPPHNKH LARVADPRSP SAGILRTPIQ VESSPQPGLP AGEQLEGLKH AQDSDPRSPT LGIARTPMKT SSGDPPSPLV KQLSEVFETE DSKSNLPPEP VLPPEAPLSS ELDLPLGTQL SVEEQMPPWN QTEFPSKQVF SKEEARQPTE TPVASQSSDK PSRDPETPRS SGSMRNRWKP NSSKVLGRSP LTILQDDNSP GTLTLRQGKR PSPLSENVSE LKEGAILGTG RLLKTGGRAW EQGQDHDKEN QHFPLVES

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards