SPRY domain-containing SOCS box protein 2 (SPSB2)

About SPRY domain-containing SOCS box protein 2

SPRY domain-containing SOCS box protein 2 (SPSB2) is a protein from Homo sapiens identified by UniProt accession Q99619, 263 residues long. MolForge cross-references it against 0 known binders and 57 disease associations.

Target properties

Protein name	SPRY domain-containing SOCS box protein 2
UniProt accession	Q99619
Gene	SPSB2
Organism	Homo sapiens
Length	263 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (57)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.31
clear cell renal carcinoma · score 0.18
Myopia · score 0.18
Hypermetropia · score 0.18
refractive error measurement · score 0.16
hyperopia · score 0.14
systolic blood pressure · score 0.13
self reported educational attainment · score 0.13
blood protein measurement · score 0.12
retinal vasculature measurement · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99619-F1	alphafold	PREDICTED	87.62	—

Amino-acid sequence (263 residues)

MGQTALAGGS SSTPTPQALY PDLSCPEGLE ELLSAPPPDL GAQRRHGWNP KDCSENIEVK EGGLYFERRP VAQSTDGARG KRGYSRGLHA WEISWPLEQR GTHAVVGVAT ALAPLQTDHY AALLGSNSES WGWDIGRGKL YHQSKGPGAP QYPAGTQGEQ LEVPERLLVV LDMEEGTLGY AIGGTYLGPA FRGLKGRTLY PAVSAVWGQC QVRIRYLGER RAEPHSLLHL SRLCVRHNLG DTRLGQVSAL PLPPAMKRYL LYQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards