About Prohibitin-2
Prohibitin-2 (PHB2) is a protein
from Homo sapiens identified by UniProt accession
Q99623, 299 residues long.
MolForge cross-references it against 0 known binders and
189 disease associations.
Target properties
| Protein name | Prohibitin-2 |
|---|
| UniProt accession | Q99623 |
|---|
| Gene | PHB2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 299 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (189)
Diseases linked to this target (Open Targets).
- oleic acid measurement · score 0.18
- fatty acid measurement · score 0.17
- non-small cell lung carcinoma · score 0.10
- mean corpuscular hemoglobin concentration · score 0.09
- hepatocellular carcinoma · score 0.09
- neoplasm · score 0.08
- esophageal squamous cell carcinoma · score 0.07
- primary ovarian insufficiency · score 0.07
- cardiomyopathy · score 0.07
- 46,XX gonadal dysgenesis · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99623-F1 | alphafold | PREDICTED | 85.13 | — |
Amino-acid sequence (299 residues)
MAQNLKDLAG RLPAGPRGMG TALKLLLGAG AVAYGVRESV FTVEGGHRAI FFNRIGGVQQ DTILAEGLHF RIPWFQYPII YDIRARPRKI SSPTGSKDLQ MVNISLRVLS RPNAQELPSM YQRLGLDYEE RVLPSIVNEV LKSVVAKFNA SQLITQRAQV SLLIRRELTE RAKDFSLILD DVAITELSFS REYTAAVEAK QVAQQEAQRA QFLVEKAKQE QRQKIVQAEG EAEAAKMLGE ALSKNPGYIK LRKIRAAQNI SKTIATSQNR IYLTADNLVL NLQDESFTRG SDSLIKGKK
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