About Sodium-coupled neutral amino acid transporter 3
Sodium-coupled neutral amino acid transporter 3 (SLC38A3) is a protein
from Homo sapiens identified by UniProt accession
Q99624, 504 residues long.
MolForge cross-references it against 0 known binders and
166 disease associations.
Target properties
| Protein name | Sodium-coupled neutral amino acid transporter 3 |
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| UniProt accession | Q99624 |
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| Gene | SLC38A3 |
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| Organism | Homo sapiens |
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| Length | 504 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (166)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- undetermined early-onset epileptic encephalopathy · score 0.37
- neuroinflammatory disorder · score 0.34
- genetic disorder · score 0.19
- smoking behavior · score 0.18
- Short stature · score 0.15
- self reported educational attainment · score 0.10
- female reproductive system disease · score 0.10
- mean corpuscular hemoglobin · score 0.09
- appendicular lean mass · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99624-F1 | alphafold | PREDICTED | 78.55 | — |
Amino-acid sequence (504 residues)
MEAPLQTEMV ELVPNGKHSE GLLPVITPMA GNQRVEDPAR SCMEGKSFLQ KSPSKEPHFT DFEGKTSFGM SVFNLSNAIM GSGILGLAYA MANTGIILFL FLLTAVALLS SYSIHLLLKS SGVVGIRAYE QLGYRAFGTP GKLAAALAIT LQNIGAMSSY LYIIKSELPL VIQTFLNLEE KTSDWYMNGN YLVILVSVTI ILPLALMRQL GYLGYSSGFS LSCMVFFLIA VIYKKFHVPC PLPPNFNNTT GNFSHVEIVK EKVQLQVEPE ASAFCTPSYF TLNSQTAYTI PIMAFAFVCH PEVLPIYTEL KDPSKKKMQH ISNLSIAVMY IMYFLAALFG YLTFYNGVES ELLHTYSKVD PFDVLILCVR VAVLTAVTLT VPIVLFPVRR AIQQMLFPNQ EFSWLRHVLI AVGLLTCINL LVIFAPNILG IFGVIGATSA PFLIFIFPAI FYFRIMPTEK EPARSTPKIL ALCFAMLGFL LMTMSLSFII IDWASGTSRH GGNH
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