Homeobox protein CDX-2 (CDX2)

About Homeobox protein CDX-2

Homeobox protein CDX-2 (CDX2) is a protein from Homo sapiens identified by UniProt accession Q99626, 313 residues long. MolForge cross-references it against 0 known binders and 567 disease associations.

Target properties

Protein name	Homeobox protein CDX-2
UniProt accession	Q99626
Gene	CDX2
Organism	Homo sapiens
Length	313 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (567)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
multiple congenital anomalies/dysmorphic syndrome-intellectual disability · score 0.50
gastrointestinal stromal tumor · score 0.38
lung carcinoma · score 0.37
Endometrial Endometrioid Adenocarcinoma · score 0.37
nodular melanoma · score 0.37
superficial spreading melanoma · score 0.37
esophageal adenocarcinoma · score 0.29
gastric carcinoma · score 0.29
colorectal adenocarcinoma · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99626-F1	alphafold	PREDICTED	61.63	—

Amino-acid sequence (313 residues)

MYVSYLLDKD VSMYPSSVRH SGGLNLAPQN FVSPPQYPDY GGYHVAAAAA AAANLDSAQS PGPSWPAAYG APLREDWNGY APGGAAAAAN AVAHGLNGGS PAAAMGYSSP ADYHPHHHPH HHPHHPAAAP SCASGLLQTL NPGPPGPAAT AAAEQLSPGG QRRNLCEWMR KPAQQSLGSQ VKTRTKDKYR VVYTDHQRLE LEKEFHYSRY ITIRRKAELA ATLGLSERQV KIWFQNRRAK ERKINKKKLQ QQQQQQPPQP PPPPPQPPQP QPGPLRSVPE PLSPVSSLQA SVPGSVPGVL GPTGGVLNPT VTQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards