About COP9 signalosome complex subunit 8
COP9 signalosome complex subunit 8 (COPS8) is a protein
from Homo sapiens identified by UniProt accession
Q99627, 209 residues long.
MolForge cross-references it against 0 known binders and
80 disease associations.
Target properties
| Protein name | COP9 signalosome complex subunit 8 |
|---|
| UniProt accession | Q99627 |
|---|
| Gene | COPS8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 209 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (80)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- neutrophil count · score 0.25
- leukocyte count · score 0.24
- myeloid white cell count · score 0.23
- monocyte count · score 0.23
- gut microbiome measurement · score 0.23
- bone density · score 0.23
- breast adenocarcinoma · score 0.18
- neuroimaging measurement · score 0.17
- cortical thickness · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99627-F1 | alphafold | PREDICTED | 85.12 | — |
Amino-acid sequence (209 residues)
MPVAVMAESA FSFKKLLDQC ENQELEAPGG IATPPVYGQL LALYLLHNDM NNARYLWKRI PPAIKSANSE LGGIWSVGQR IWQRDFPGIY TTINAHQWSE TVQPIMEALR DATRRRAFAL VSQAYTSIIA DDFAAFVGLP VEEAVKGILE QGWQADSTTR MVLPRKPVAG ALDVSFNKFI PLSEPAPVPP IPNEQQLARL TDYVAFLEN
Explore COP9 signalosome complex subunit 8 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets