Pre-mRNA-splicing factor 18 (PRPF18)

About Pre-mRNA-splicing factor 18

Pre-mRNA-splicing factor 18 (PRPF18) is a protein from Homo sapiens identified by UniProt accession Q99633, 342 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.

Target properties

Protein name	Pre-mRNA-splicing factor 18
UniProt accession	Q99633
Gene	PRPF18
Organism	Homo sapiens
Length	342 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (32)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.49
severe intellectual disability-corpus callosum agenesis-facial dysmorphism-cerebellar ataxia syndrome · score 0.27
skin pigmentation · score 0.18
cortical surface area measurement · score 0.14
brain measurement · score 0.12
hemoglobin measurement · score 0.12
Red cell distribution width · score 0.12
FEV/FVC ratio · score 0.11
erythrocyte count · score 0.11
hematocrit · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99633-F1	alphafold	PREDICTED	77.00	—

Amino-acid sequence (342 residues)

MDILKSEILR KRQLVEDRNL LVENKKYFKR SELAKKEEEA YFERCGYKIQ PKEEDQKPLT SSNPVLELEL AEEKLPMTLS RQEVIRRLRE RGEPIRLFGE TDYDAFQRLR KIEILTPEVN KGLRNDLKAA LDKIDQQYLN EIVGGQEPGE EDTQNDLKVH EENTTIEELE ALGESLGKGD DHKDMDIITK FLKFLLGVWA KELNAREDYV KRSVQGKLNS ATQKQTESYL RPLFRKLRKR NLPADIKESI TDIIKFMLQR EYVKANDAYL QMAIGNAPWP IGVTMVGIHA RTGREKIFSK HVAHVLNDET QRKYIQGLKR LMTICQKHFP TDPSKCVEYN AL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards