About Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) is a protein
from Homo sapiens identified by UniProt accession
Q99640, 499 residues long.
MolForge cross-references it against 0 known binders and
86 disease associations.
Target properties
| Protein name | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase |
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| UniProt accession | Q99640 |
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| Gene | PKMYT1 |
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| Organism | Homo sapiens |
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| Length | 499 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (86)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- breast adenocarcinoma · score 0.26
- lung adenocarcinoma · score 0.24
- endometrial cancer · score 0.23
- esophageal cancer · score 0.17
- balding measurement · score 0.15
- neoplasm · score 0.10
- gastric adenocarcinoma · score 0.10
- triple-negative breast cancer · score 0.10
- nonpapillary renal cell carcinoma · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99640-F1 | alphafold | PREDICTED | 75.67 | — |
Amino-acid sequence (499 residues)
MLERPPALAM PMPTEGTPPP LSGTPIPVPA YFRHAEPGFS LKRPRGLSRS LPPPPPAKGS IPISRLFPPR TPGWHQLQPR RVSFRGEASE TLQSPGYDPS RPESFFQQSF QRLSRLGHGS YGEVFKVRSK EDGRLYAVKR SMSPFRGPKD RARKLAEVGS HEKVGQHPCC VRLEQAWEEG GILYLQTELC GPSLQQHCEA WGASLPEAQV WGYLRDTLLA LAHLHSQGLV HLDVKPANIF LGPRGRCKLG DFGLLVELGT AGAGEVQEGD PRYMAPELLQ GSYGTAADVF SLGLTILEVA CNMELPHGGE GWQQLRQGYL PPEFTAGLSS ELRSVLVMML EPDPKLRATA EALLALPVLR QPRAWGVLWC MAAEALSRGW ALWQALLALL CWLWHGLAHP ASWLQPLGPP ATPPGSPPCS LLLDSSLSSN WDDDSLGPSL SPEAVLARTV GSTSTPRSRC TPRDALDLSD INSEPPRGSF PSFEPRNLLS LFEDTLDPT
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