About Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (SDHC) is a protein
from Homo sapiens identified by UniProt accession
Q99643, 169 residues long.
MolForge cross-references it against 0 known binders and
202 disease associations.
Target properties
| Protein name | Succinate dehydrogenase cytochrome b560 subunit, mitochondrial |
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| UniProt accession | Q99643 |
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| Gene | SDHC |
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| Organism | Homo sapiens |
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| Length | 169 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (202)
Diseases linked to this target (Open Targets).
- hereditary pheochromocytoma-paraganglioma · score 0.77
- Carney-Stratakis syndrome · score 0.72
- gastrointestinal stromal tumor · score 0.71
- Inherited cancer-predisposing syndrome · score 0.55
- hereditary neoplastic syndrome · score 0.55
- neurodegenerative disease · score 0.52
- malignant endocrine neoplasm · score 0.37
- Cowden disease · score 0.37
- endocrine neoplasm · score 0.37
- lung carcinoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99643-F1 | alphafold | PREDICTED | 91.15 | — |
Amino-acid sequence (169 residues)
MAALLLRHVG RHCLRAHFSP QLCIRNAVPL GTTAKEEMER FWNKNIGSNR PLSPHITIYS WSLPMAMSIC HRGTGIALSA GVSLFGMSAL LLPGNFESYL ELVKSLCLGP ALIHTAKFAL VFPLMYHTWN GIRHLMWDLG KGLKIPQLYQ SGVVVLVLTV LSSMGLAAM
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