About Calcineurin B homologous protein 1
Calcineurin B homologous protein 1 (CHP1) is a protein
from Homo sapiens identified by UniProt accession
Q99653, 195 residues long.
MolForge cross-references it against 0 known binders and
293 disease associations.
Target properties
| Protein name | Calcineurin B homologous protein 1 |
|---|
| UniProt accession | Q99653 |
|---|
| Gene | CHP1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 195 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (293)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.49
- autosomal recessive spastic ataxia · score 0.40
- leukocyte count · score 0.29
- lysosomal storage disease · score 0.27
- cystatin C measurement · score 0.23
- creatinine measurement · score 0.17
- systolic blood pressure · score 0.16
- age at menopause · score 0.16
- vital capacity · score 0.13
- hemoglobin measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99653-F1 | alphafold | PREDICTED | 89.16 | — |
Amino-acid sequence (195 residues)
MGSRASTLLR DEELEEIKKE TGFSHSQITR LYSRFTSLDK GENGTLSRED FQRIPELAIN PLGDRIINAF FPEGEDQVNF RGFMRTLAHF RPIEDNEKSK DVNGPEPLNS RSNKLHFAFR LYDLDKDEKI SRDELLQVLR MMVGVNISDE QLGSIADRTI QEADQDGDSA ISFTEFVKVL EKVDVEQKMS IRFLH
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