About Kinesin-like protein KIF2C
Kinesin-like protein KIF2C (KIF2C) is a protein
from Homo sapiens identified by UniProt accession
Q99661, 725 residues long.
MolForge cross-references it against 0 known binders and
148 disease associations.
Target properties
| Protein name | Kinesin-like protein KIF2C |
|---|
| UniProt accession | Q99661 |
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| Gene | KIF2C |
|---|
| Organism | Homo sapiens |
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| Length | 725 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (148)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- ovarian cancer · score 0.18
- breast adenocarcinoma · score 0.18
- Red cell distribution width · score 0.14
- hepatocellular carcinoma · score 0.12
- neoplasm · score 0.11
- cancer · score 0.09
- non-small cell lung carcinoma · score 0.09
- intraocular pressure measurement · score 0.08
- platelet component distribution width · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99661-F1 | alphafold | PREDICTED | 74.20 | — |
Amino-acid sequence (725 residues)
MAMDSSLQAR LFPGLAIKIQ RSNGLIHSAN VRTVNLEKSC VSVEWAEGGA TKGKEIDFDD VAAINPELLQ LLPLHPKDNL PLQENVTIQK QKRRSVNSKI PAPKESLRSR STRMSTVSEL RITAQENDME VELPAAANSR KQFSVPPAPT RPSCPAVAEI PLRMVSEEME EQVHSIRGSS SANPVNSVRR KSCLVKEVEK MKNKREEKKA QNSEMRMKRA QEYDSSFPNW EFARMIKEFR ATLECHPLTM TDPIEEHRIC VCVRKRPLNK QELAKKEIDV ISIPSKCLLL VHEPKLKVDL TKYLENQAFC FDFAFDETAS NEVVYRFTAR PLVQTIFEGG KATCFAYGQT GSGKTHTMGG DLSGKAQNAS KGIYAMASRD VFLLKNQPCY RKLGLEVYVT FFEIYNGKLF DLLNKKAKLR VLEDGKQQVQ VVGLQEHLVN SADDVIKMID MGSACRTSGQ TFANSNSSRS HACFQIILRA KGRMHGKFSL VDLAGNERGA DTSSADRQTR MEGAEINKSL LALKECIRAL GQNKAHTPFR ESKLTQVLRD SFIGENSRTC MIATISPGIS SCEYTLNTLR YADRVKELSP HSGPSGEQLI QMETEEMEAC SNGALIPGNL SKEEEELSSQ MSSFNEAMTQ IRELEEKAME ELKEIIQQGP DWLELSEMTE QPDYDLETFV NKAESALAQQ AKHFSALRDV IKALRLAMQL EEQASRQISS KKRPQ
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