About Cell growth regulator with RING finger domain protein 1
Cell growth regulator with RING finger domain protein 1 (CGRRF1) is a protein
from Homo sapiens identified by UniProt accession
Q99675, 332 residues long.
MolForge cross-references it against 0 known binders and
32 disease associations.
Target properties
| Protein name | Cell growth regulator with RING finger domain protein 1 |
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| UniProt accession | Q99675 |
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| Gene | CGRRF1 |
|---|
| Organism | Homo sapiens |
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| Length | 332 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (32)
Diseases linked to this target (Open Targets).
- refractive error · score 0.05
- platelet crit · score 0.05
- refractive error measurement · score 0.04
- reticulocyte count · score 0.04
- cortical surface area measurement · score 0.04
- reticulocyte measurement · score 0.03
- Myopia · score 0.03
- neoplasm · score 0.03
- platelet count · score 0.03
- Immature Reticulocyte Fraction Measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99675-F1 | alphafold | PREDICTED | 80.20 | — |
Amino-acid sequence (332 residues)
MAAVFLVTLY EYSPLFYIAV VFTCFIVTTG LVLGWFGWDV PVILRNSEET QFSTRVFKKQ MRQVKNPFGL EITNPSSASI TTGITLTTDC LEDSLLTCYW GCSVQKLYEA LQKHVYCFRI STPQALEDAL YSEYLYQEQY FIKKDSKEEI YCQLPRDTKI EDFGTVPRSR YPLVALLTLA DEDDREIYDI ISMVSVIHIP DRTYKLSCRI LYQYLLLAQG QFHDLKQLFM SANNNFTPSN NSSSEEKNTD RSLLEKVGLS ESEVEPSEEN SKDCVVCQNG TVNWVLLPCR HTCLCDGCVK YFQQCPMCRQ FVQESFALCS QKEQDKDKPK TL
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