G-protein coupled receptor 20 (GPR20)

About G-protein coupled receptor 20

G-protein coupled receptor 20 (GPR20) is a protein from Homo sapiens identified by UniProt accession Q99678, 358 residues long. MolForge cross-references it against 0 known binders and 80 disease associations.

Target properties

Protein name	G-protein coupled receptor 20
UniProt accession	Q99678
Gene	GPR20
Organism	Homo sapiens
Length	358 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (80)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.50
systolic blood pressure · score 0.43
diastolic blood pressure · score 0.42
body height · score 0.39
FEV/FVC ratio · score 0.24
neutrophil count · score 0.22
self reported educational attainment · score 0.22
lean body mass · score 0.22
body mass index · score 0.22
body fat percentage · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99678-F1	alphafold	PREDICTED	78.89	—

Amino-acid sequence (358 residues)

MPSVSPAGPS AGAVPNATAV TTVRTNASGL EVPLFHLFAR LDEELHGTFP GLWLALMAVH GAIFLAGLVL NGLALYVFCC RTRAKTPSVI YTINLVVTDL LVGLSLPTRF AVYYGARGCL RCAFPHVLGY FLNMHCSILF LTCICVDRYL AIVRPEGSRR CRQPACARAV CAFVWLAAGA VTLSVLGVTG SRPCCRVFAL TVLEFLLPLL VISVFTGRIM CALSRPGLLH QGRQRRVRAM QLLLTVLIIF LVCFTPFHAR QVAVALWPDM PHHTSLVVYH VAVTLSSLNS CMDPIVYCFV TSGFQATVRG LFGQHGEREP SSGDVVSMHR SSKGSGRHHI LSAGPHALTQ ALANGPEA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards