Probable G-protein coupled receptor 21 (GPR21)

About Probable G-protein coupled receptor 21

Probable G-protein coupled receptor 21 (GPR21) is a protein from Homo sapiens identified by UniProt accession Q99679, 349 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.

Target properties

Protein name	Probable G-protein coupled receptor 21
UniProt accession	Q99679
Gene	GPR21
Organism	Homo sapiens
Length	349 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (28)

Diseases linked to this target (Open Targets).

myeloid white cell count · score 0.05
type 2 diabetes mellitus · score 0.04
vitamin D measurement · score 0.04
MODY · score 0.04
permanent neonatal diabetes mellitus 1 · score 0.04
birth weight · score 0.03
lymphocyte count · score 0.03
aspartate aminotransferase measurement · score 0.02
lymphocyte percentage of leukocytes · score 0.02
pulse pressure measurement · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99679-F1	alphafold	PREDICTED	83.14	—

Amino-acid sequence (349 residues)

MNSTLDGNQS SHPFCLLAFG YLETVNFCLL EVLIIVFLTV LIISGNIIVI FVFHCAPLLN HHTTSYFIQT MAYADLFVGV SCVVPSLSLL HHPLPVEESL TCQIFGFVVS VLKSVSMASL ACISIDRYIA ITKPLTYNTL VTPWRLRLCI FLIWLYSTLV FLPSFFHWGK PGYHGDVFQW CAESWHTDSY FTLFIVMMLY APAALIVCFT YFNIFRICQQ HTKDISERQA RFSSQSGETG EVQACPDKRY AMVLFRITSV FYILWLPYII YFLLESSTGH SNRFASFLTT WLAISNSFCN CVIYSLSNSV FQRGLKRLSG AMCTSCASQT TANDPYTVRS KGPLNGCHI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards