G-protein coupled receptor 22 (GPR22)

About G-protein coupled receptor 22

G-protein coupled receptor 22 (GPR22) is a protein from Homo sapiens identified by UniProt accession Q99680, 433 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.

Target properties

Protein name	G-protein coupled receptor 22
UniProt accession	Q99680
Gene	GPR22
Organism	Homo sapiens
Length	433 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99680-F1	alphafold	PREDICTED	72.35	—

Amino-acid sequence (433 residues)

MCFSPILEIN MQSESNITVR DDIDDINTNM YQPLSYPLSF QVSLTGFLML EIVLGLGSNL TVLVLYCMKS NLINSVSNII TMNLHVLDVI ICVGCIPLTI VILLLSLESN TALICCFHEA CVSFASVSTA INVFAITLDR YDISVKPANR ILTMGRAVML MISIWIFSFF SFLIPFIEVN FFSLQSGNTW ENKTLLCVST NEYYTELGMY YHLLVQIPIF FFTVVVMLIT YTKILQALNI RIGTRFSTGQ KKKARKKKTI SLTTQHEATD MSQSSGGRNV VFGVRTSVSV IIALRRAVKR HRERRERQKR VFRMSLLIIS TFLLCWTPIS VLNTTILCLG PSDLLVKLRL CFLVMAYGTT IFHPLLYAFT RQKFQKVLKS KMKKRVVSIV EADPLPNNAV IHNSWIDPKR NKKITFEDSE IREKCLVPQV VTD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards