About Zinc finger protein Gfi-1
Zinc finger protein Gfi-1 (GFI1) is a protein
from Homo sapiens identified by UniProt accession
Q99684, 422 residues long.
MolForge cross-references it against 0 known binders and
289 disease associations.
Target properties
| Protein name | Zinc finger protein Gfi-1 |
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| UniProt accession | Q99684 |
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| Gene | GFI1 |
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| Organism | Homo sapiens |
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| Length | 422 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (289)
Diseases linked to this target (Open Targets).
- neutropenia, severe congenital, 2, autosomal dominant · score 0.73
- nonimmune chronic idiopathic neutropenia of adults · score 0.67
- severe congenital neutropenia · score 0.51
- constitutional neutropenia · score 0.47
- autosomal dominant severe congenital neutropenia · score 0.37
- monocyte count · score 0.36
- monocyte percentage of leukocytes · score 0.33
- apolipoprotein B measurement · score 0.31
- total cholesterol measurement · score 0.31
- testosterone measurement · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99684-F1 | alphafold | PREDICTED | 56.75 | — |
Amino-acid sequence (422 residues)
MPRSFLVKSK KAHSYHQPRS PGPDYSLRLE NVPAPSRADS TSNAGGAKAE PRDRLSPESQ LTEAPDRASA SPDSCEGSVC ERSSEFEDFW RPPSPSASPA SEKSMCPSLD EAQPFPLPFK PYSWSGLAGS DLRHLVQSYR PCGALERGAG LGLFCEPAPE PGHPAALYGP KRAAGGAGAG APGSCSAGAG ATAGPGLGLY GDFGSAAAGL YERPTAAAGL LYPERGHGLH ADKGAGVKVE SELLCTRLLL GGGSYKCIKC SKVFSTPHGL EVHVRRSHSG TRPFACEMCG KTFGHAVSLE QHKAVHSQER SFDCKICGKS FKRSSTLSTH LLIHSDTRPY PCQYCGKRFH QKSDMKKHTF IHTGEKPHKC QVCGKAFSQS SNLITHSRKH TGFKPFGCDL CGKGFQRKVD LRRHRETQHG LK
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