About Monoglyceride lipase
Monoglyceride lipase (MGLL) is a protein
from Homo sapiens identified by UniProt accession
Q99685, 303 residues long.
MolForge cross-references it against 0 known binders and
264 disease associations.
Target properties
| Protein name | Monoglyceride lipase |
|---|
| UniProt accession | Q99685 |
|---|
| Gene | MGLL |
|---|
| Organism | Homo sapiens |
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| Length | 303 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (264)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.26
- musculoskeletal system disease · score 0.13
- Primary amenorrhea · score 0.12
- neoplasm · score 0.11
- bone density · score 0.11
- urate measurement · score 0.11
- hepatocellular carcinoma · score 0.10
- glycine measurement · score 0.10
- prostate carcinoma · score 0.09
- Tourette syndrome · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99685-F1 | alphafold | PREDICTED | 93.90 | — |
Amino-acid sequence (303 residues)
MPEESSPRRT PQSIPYQDLP HLVNADGQYL FCRYWKPTGT PKALIFVSHG AGEHSGRYEE LARMLMGLDL LVFAHDHVGH GQSEGERMVV SDFHVFVRDV LQHVDSMQKD YPGLPVFLLG HSMGGAIAIL TAAERPGHFA GMVLISPLVL ANPESATTFK VLAAKVLNLV LPNLSLGPID SSVLSRNKTE VDIYNSDPLI CRAGLKVCFG IQLLNAVSRV ERALPKLTVP FLLLQGSADR LCDSKGAYLL MELAKSQDKT LKIYEGAYHV LHKELPEVTN SVFHEINMWV SQRTATAGTA SPP
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