Fasciculation and elongation protein zeta-1 (FEZ1)

About Fasciculation and elongation protein zeta-1

Fasciculation and elongation protein zeta-1 (FEZ1) is a protein from Homo sapiens identified by UniProt accession Q99689, 392 residues long. MolForge cross-references it against 0 known binders and 69 disease associations.

Target properties

Protein name	Fasciculation and elongation protein zeta-1
UniProt accession	Q99689
Gene	FEZ1
Organism	Homo sapiens
Length	392 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (69)

Diseases linked to this target (Open Targets).

brain measurement · score 0.27
Intellectual disability · score 0.26
serum alanine aminotransferase measurement · score 0.23
aspartate aminotransferase measurement · score 0.21
platelet count · score 0.12
drug use measurement · score 0.12
bone measurement · score 0.09
heel bone mineral density · score 0.08
vital capacity · score 0.07
mean corpuscular volume · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99689-F1	alphafold	PREDICTED	67.43	—

Amino-acid sequence (392 residues)

MEAPLVSLDE EFEDLRPSCS EDPEEKPQCF YGSSPHHLED PSLSELENFS SEIISFKSME DLVNEFDEKL NVCFRNYNAK TENLAPVKNQ LQIQEEEETL QDEEVWDALT DNYIPSLSED WRDPNIEALN GNCSDTEIHE KEEEEFNEKS ENDSGINEEP LLTADQVIEE IEEMMQNSPD PEEEEEVLEE EDGGETSSQA DSVLLQEMQA LTQTFNNNWS YEGLRHMSGS ELTELLDQVE GAIRDFSEEL VQQLARRDEL EFEKEVKNSF ITVLIEVQNK QKEQRELMKK RRKEKGLSLQ SSRIEKGNQM PLKRFSMEGI SNILQSGIRQ TFGSSGTDKQ YLNTVIPYEK KASPPSVEDL QMLTNILFAM KEDNEKVPTL LTDYILKVLC PT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards