About Pituitary homeobox 2
Pituitary homeobox 2 (PITX2) is a protein
from Homo sapiens identified by UniProt accession
Q99697, 317 residues long.
MolForge cross-references it against 0 known binders and
733 disease associations.
Target properties
| Protein name | Pituitary homeobox 2 |
|---|
| UniProt accession | Q99697 |
|---|
| Gene | PITX2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 317 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (733)
Diseases linked to this target (Open Targets).
- Axenfeld-Rieger syndrome type 1 · score 0.81
- anterior segment dysgenesis 4 · score 0.78
- ring dermoid of cornea · score 0.72
- Rieger anomaly · score 0.65
- atrial fibrillation · score 0.53
- neurodegenerative disease · score 0.53
- Peters anomaly · score 0.52
- Axenfeld-Rieger syndrome · score 0.48
- genetic disorder · score 0.46
- Ocular anterior segment dysgenesis · score 0.45
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99697-F1 | alphafold | PREDICTED | 61.31 | — |
Amino-acid sequence (317 residues)
METNCRKLVS ACVQLGVQPA AVECLFSKDS EIKKVEFTDS PESRKEAASS KFFPRQHPGA NEKDKSQQGK NEDVGAEDPS KKKRQRRQRT HFTSQQLQEL EATFQRNRYP DMSTREEIAV WTNLTEARVR VWFKNRRAKW RKRERNQQAE LCKNGFGPQF NGLMQPYDDM YPGYSYNNWA AKGLTSASLS TKSFPFFNSM NVNPLSSQSM FSPPNSISSM SMSSSMVPSA VTGVPGSSLN SLNNLNNLSS PSLNSAVPTP ACPYAPPTPP YVYRDTCNSS LASLRLKAKQ HSSFGYASVQ NPASNLSACQ YAVDRPV
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