Melanin-concentrating hormone receptor 1 (MCHR1)

About Melanin-concentrating hormone receptor 1

Melanin-concentrating hormone receptor 1 (MCHR1) is a protein from Homo sapiens identified by UniProt accession Q99705, 353 residues long. MolForge cross-references it against 0 known binders and 159 disease associations.

Target properties

Protein name	Melanin-concentrating hormone receptor 1
UniProt accession	Q99705
Gene	MCHR1
Organism	Homo sapiens
Length	353 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (159)

Diseases linked to this target (Open Targets).

glioblastoma multiforme · score 0.27
breast adenocarcinoma · score 0.25
neuroticism measurement · score 0.10
prostate adenocarcinoma · score 0.10
calcium measurement · score 0.06
Kallmann syndrome · score 0.06
obesity due to melanocortin 4 receptor deficiency · score 0.06
Osteoporosis · score 0.05
Obesity · score 0.05
bipolar disorder · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99705-F1	alphafold	PREDICTED	84.43	—

Amino-acid sequence (353 residues)

MDLEASLLPT GPNASNTSDG PDNLTSAGSP PRTGSISYIN IIMPSVFGTI CLLGIIGNST VIFAVVKKSK LHWCNNVPDI FIINLSVVDL LFLLGMPFMI HQLMGNGVWH FGETMCTLIT AMDANSQFTS TYILTAMAID RYLATVHPIS STKFRKPSVA TLVICLLWAL SFISITPVWL YARLIPFPGG AVGCGIRLPN PDTDLYWFTL YQFFLAFALP FVVITAAYVR ILQRMTSSVA PASQRSIRLR TKRVTRTAIA ICLVFFVCWA PYYVLQLTQL SISRPTLTFV YLYNAAISLG YANSCLNPFV YIVLCETFRK RLVLSVKPAA QGQLRAVSNA QTADEERTES KGT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards