About Killer cell immunoglobulin-like receptor 2DL4
Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4) is a protein
from Homo sapiens identified by UniProt accession
Q99706, 377 residues long.
MolForge cross-references it against 0 known binders and
70 disease associations.
Target properties
| Protein name | Killer cell immunoglobulin-like receptor 2DL4 |
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| UniProt accession | Q99706 |
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| Gene | KIR2DL4 |
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| Organism | Homo sapiens |
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| Length | 377 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (70)
Diseases linked to this target (Open Targets).
- neoplasm · score 0.05
- infect · score 0.05
- infection · score 0.05
- pancreatic adenocarcinoma · score 0.04
- acute myeloid leukemia · score 0.03
- Systemic lupus erythematosus · score 0.03
- Langerhans Cell Histiocytosis · score 0.03
- 3-hydroxypropylmercapturic acid measurement · score 0.03
- renal cell carcinoma · score 0.02
- lissencephaly with cerebellar hypoplasia · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99706-F1 | alphafold | PREDICTED | 69.97 | — |
Amino-acid sequence (377 residues)
MSMSPTVIIL ACLGFFLDQS VWAHVGGQDK PFCSAWPSAV VPQGGHVTLR CHYRRGFNIF TLYKKDGVPV PELYNRIFWN SFLISPVTPA HAGTYRCRGF HPHSPTEWSA PSNPLVIMVT GLYEKPSLTA RPGPTVRAGE NVTLSCSSQS SFDIYHLSRE GEAHELRLPA VPSINGTFQA DFPLGPATHG ETYRCFGSFH GSPYEWSDPS DPLPVSVTGN PSSSWPSPTE PSFKTGIARH LHAVIRYSVA IILFTILPFF LLHRWCSKKK DAAVMNQEPA GHRTVNREDS DEQDPQEVTY AQLDHCIFTQ RKITGPSQRS KRPSTDTSVC IELPNAEPRA LSPAHEHHSQ ALMGSSRETT ALSQTQLASS NVPAAGI
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