3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)

About 3-hydroxyacyl-CoA dehydrogenase type-2

3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) is a protein from Homo sapiens identified by UniProt accession Q99714, 261 residues long. MolForge cross-references it against 0 known binders and 78 disease associations.

Target properties

Protein name	3-hydroxyacyl-CoA dehydrogenase type-2
UniProt accession	Q99714
Gene	HSD17B10
Organism	Homo sapiens
Length	261 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (78)

Diseases linked to this target (Open Targets).

HSD10 mitochondrial disease · score 0.83
HSD10 disease · score 0.78
neurodegenerative disease · score 0.55
HSD10 disease, atypical type · score 0.50
HSD10 disease, infantile type · score 0.37
HSD10 disease, neonatal type · score 0.37
Neurodevelopmental delay · score 0.34
genetic disorder · score 0.32
lysosomal storage disease · score 0.27
neoplasm · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99714-F1	alphafold	PREDICTED	96.86	—

Amino-acid sequence (261 residues)

MAAACRSVKG LVAVITGGAS GLGLATAERL VGQGASAVLL DLPNSGGEAQ AKKLGNNCVF APADVTSEKD VQTALALAKG KFGRVDVAVN CAGIAVASKT YNLKKGQTHT LEDFQRVLDV NLMGTFNVIR LVAGEMGQNE PDQGGQRGVI INTASVAAFE GQVGQAAYSA SKGGIVGMTL PIARDLAPIG IRVMTIAPGL FGTPLLTSLP EKVCNFLASQ VPFPSRLGDP AEYAHLVQAI IENPFLNGEV IRLDGAIRMQ P

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards