SMAD family member 5 (SMAD5)

About SMAD family member 5

SMAD family member 5 (SMAD5) is a protein from Homo sapiens identified by UniProt accession Q99717, 465 residues long. MolForge cross-references it against 0 known binders and 158 disease associations.

Target properties

Protein name	SMAD family member 5
UniProt accession	Q99717
Gene	SMAD5
Organism	Homo sapiens
Length	465 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (158)

Diseases linked to this target (Open Targets).

mean platelet volume · score 0.33
heel bone mineral density · score 0.29
neurodegenerative disease · score 0.23
high density lipoprotein cholesterol measurement · score 0.21
sleep duration · score 0.20
bone quantitative ultrasound measurement · score 0.20
insomnia · score 0.17
insomnia measurement · score 0.16
interleukin 9 measurement · score 0.15
neoplasm · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99717-F1	alphafold	PREDICTED	80.90	—

Amino-acid sequence (465 residues)

MTSMASLFSF TSPAVKRLLG WKQGDEEEKW AEKAVDALVK KLKKKKGAME ELEKALSSPG QPSKCVTIPR SLDGRLQVSH RKGLPHVIYC RVWRWPDLQS HHELKPLDIC EFPFGSKQKE VCINPYHYKR VESPVLPPVL VPRHNEFNPQ HSLLVQFRNL SHNEPHMPQN ATFPDSFHQP NNTPFPLSPN SPYPPSPASS TYPNSPASSG PGSPFQLPAD TPPPAYMPPD DQMGQDNSQP MDTSNNMIPQ IMPSISSRDV QPVAYEEPKH WCSIVYYELN NRVGEAFHAS STSVLVDGFT DPSNNKSRFC LGLLSNVNRN STIENTRRHI GKGVHLYYVG GEVYAECLSD SSIFVQSRNC NFHHGFHPTT VCKIPSSCSL KIFNNQEFAQ LLAQSVNHGF EAVYELTKMC TIRMSFVKGW GAEYHRQDVT STPCWIEIHL HGPLQWLDKV LTQMGSPLNP ISSVS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards