About Septin-5
Septin-5 (SEPTIN5) is a protein
from Homo sapiens identified by UniProt accession
Q99719, 369 residues long.
MolForge cross-references it against 0 known binders and
165 disease associations.
Target properties
| Protein name | Septin-5 |
|---|
| UniProt accession | Q99719 |
|---|
| Gene | SEPTIN5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 369 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (165)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.37
- bone quantitative ultrasound measurement · score 0.36
- Macrothrombocytopenia · score 0.34
- bone density · score 0.30
- platelet count · score 0.27
- mean platelet volume · score 0.24
- platelet component distribution width · score 0.23
- acute myeloid leukemia · score 0.19
- squamous cell lung carcinoma · score 0.19
- gastric adenocarcinoma · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99719-F1 | alphafold | PREDICTED | 77.49 | — |
Amino-acid sequence (369 residues)
MSTGLRYKSK LATPEDKQDI DKQYVGFATL PNQVHRKSVK KGFDFTLMVA GESGLGKSTL VHSLFLTDLY KDRKLLSAEE RISQTVEILK HTVDIEEKGV KLKLTIVDTP GFGDAVNNTE CWKPITDYVD QQFEQYFRDE SGLNRKNIQD NRVHCCLYFI SPFGHGLRPV DVGFMKALHE KVNIVPLIAK ADCLVPSEIR KLKERIREEI DKFGIHVYQF PECDSDEDED FKQQDRELKE SAPFAVIGSN TVVEAKGQRV RGRLYPWGIV EVENQAHCDF VKLRNMLIRT HMHDLKDVTC DVHYENYRAH CIQQMTSKLT QDSRMESPIP ILPLPTPDAE TEKLIRMKDE ELRRMQEMLQ RMKQQMQDQ
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