About Probable proton-coupled zinc antiporter SLC30A3
Probable proton-coupled zinc antiporter SLC30A3 (SLC30A3) is a protein
from Homo sapiens identified by UniProt accession
Q99726, 388 residues long.
MolForge cross-references it against 0 known binders and
86 disease associations.
Target properties
| Protein name | Probable proton-coupled zinc antiporter SLC30A3 |
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| UniProt accession | Q99726 |
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| Gene | SLC30A3 |
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| Organism | Homo sapiens |
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| Length | 388 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (86)
Diseases linked to this target (Open Targets).
- triglyceride measurement · score 0.24
- Febrile seizure (within the age range of 3 months to 6 years) · score 0.12
- triglyceride:HDL cholesterol ratio · score 0.10
- FTH1-related iron overload · score 0.06
- hemochromatosis type 5 · score 0.06
- zinc deficiency, transient neonatal · score 0.05
- glioblastoma multiforme · score 0.04
- central nervous system cancer · score 0.04
- hepatocellular carcinoma · score 0.04
- schizophrenia · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99726-F1 | alphafold | PREDICTED | 76.09 | — |
Amino-acid sequence (388 residues)
MEPSPAAGGL ETTRLVSPRD RGGAGGSLRL KSLFTEPSEP LPEESKPVEM PFHHCHRDPL PPPGLTPERL HARRQLYAAC AVCFVFMAGE VVGGYLAHSL AIMTDAAHLL ADVGSMMGSL FSLWLSTRPA TRTMTFGWHR SETLGALASV VSLWMVTGIL LYLAFVRLLH SDYHIEGGAM LLTASIAVCA NLLMAFVLHQ AGPPHSHGSR GAEYAPLEEG PEEPLPLGNT SVRAAFVHVL GDLLQSFGVL AASILIYFKP QYKAADPIST FLFSICALGS TAPTLRDVLR ILMEGTPRNV GFEPVRDTLL SVPGVRATHE LHLWALTLTY HVASAHLAID STADPEAVLA EASSRLYSRF GFSSCTLQVE QYQPEMAQCL RCQEPPQA
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