Metalloproteinase inhibitor 4 (TIMP4)

About Metalloproteinase inhibitor 4

Metalloproteinase inhibitor 4 (TIMP4) is a protein from Homo sapiens identified by UniProt accession Q99727, 224 residues long. MolForge cross-references it against 0 known binders and 312 disease associations.

Target properties

Protein name	Metalloproteinase inhibitor 4
UniProt accession	Q99727
Gene	TIMP4
Organism	Homo sapiens
Length	224 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99727-F1	alphafold	PREDICTED	88.17	—

Amino-acid sequence (224 residues)

MPGSPRPAPS WVLLLRLLAL LRPPGLGEAC SCAPAHPQQH ICHSALVIRA KISSEKVVPA SADPADTEKM LRYEIKQIKM FKGFEKVKDV QYIYTPFDSS LCGVKLEANS QKQYLLTGQV LSDGKVFIHL CNYIEPWEDL SLVQRESLNH HYHLNCGCQI TTCYTVPCTI SAPNECLWTD WLLERKLYGY QAQHYVCMKH VDGTCSWYRG HLPLRKEFVD IVQP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards