Nucleosome assembly protein 1-like 4 (NAP1L4)

About Nucleosome assembly protein 1-like 4

Nucleosome assembly protein 1-like 4 (NAP1L4) is a protein from Homo sapiens identified by UniProt accession Q99733, 375 residues long. MolForge cross-references it against 0 known binders and 81 disease associations.

Target properties

Protein name	Nucleosome assembly protein 1-like 4
UniProt accession	Q99733
Gene	NAP1L4
Organism	Homo sapiens
Length	375 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (81)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.50
calcium measurement · score 0.35
neutrophil count · score 0.34
aspartate aminotransferase measurement · score 0.31
leukocyte count · score 0.30
eosinophil count · score 0.29
myeloid white cell count · score 0.29
monocyte count · score 0.28
low density lipoprotein cholesterol measurement · score 0.26
reticulocyte count · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99733-F1	alphafold	PREDICTED	80.26	—

Amino-acid sequence (375 residues)

MADHSFSDGV PSDSVEAAKN ASNTEKLTDQ VMQNPRVLAA LQERLDNVPH TPSSYIETLP KAVKRRINAL KQLQVRCAHI EAKFYEEVHD LERKYAALYQ PLFDKRREFI TGDVEPTDAE SEWHSENEEE EKLAGDMKSK VVVTEKAAAT AEEPDPKGIP EFWFTIFRNV DMLSELVQEY DEPILKHLQD IKVKFSDPGQ PMSFVLEFHF EPNDYFTNSV LTKTYKMKSE PDKADPFSFE GPEIVDCDGC TIDWKKGKNV TVKTIKKKQK HKGRGTVRTI TKQVPNESFF NFFNPLKASG DGESLDEDSE FTLASDFEIG HFFRERIVPR AVLYFTGEAI EDDDNFEEGE EGEEEELEGD EEGEDEDDAE INPKV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards