Gamma-soluble NSF attachment protein (NAPG)

About Gamma-soluble NSF attachment protein

Gamma-soluble NSF attachment protein (NAPG) is a protein from Homo sapiens identified by UniProt accession Q99747, 312 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.

Target properties

Protein name	Gamma-soluble NSF attachment protein
UniProt accession	Q99747
Gene	NAPG
Organism	Homo sapiens
Length	312 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (32)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.54
FEV/FVC ratio · score 0.32
lysosomal storage disease · score 0.25
gut microbiome measurement · score 0.24
taxonomic microbiome measurement · score 0.24
cortical surface area measurement · score 0.14
heel bone mineral density · score 0.10
hair shape measurement · score 0.09
balding measurement · score 0.09
bone quantitative ultrasound measurement · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99747-F1	alphafold	PREDICTED	91.09	—

Amino-acid sequence (312 residues)

MAAQKINEGL EHLAKAEKYL KTGFLKWKPD YDSAASEYGK AAVAFKNAKQ FEQAKDACLR EAVAHENNRA LFHAAKAYEQ AGMMLKEMQK LPEAVQLIEK ASMMYLENGT PDTAAMALER AGKLIENVDP EKAVQLYQQT ANVFENEERL RQAVELLGKA SRLLVRGRRF DEAALSIQKE KNIYKEIENY PTCYKKTIAQ VLVHLHRNDY VAAERCVRES YSIPGFNGSE DCAALEQLLE GYDQQDQDQV SDVCNSPLFK YMDNDYAKLG LSLVVPGGGI KKKSPATPQA KPDGVTATAA DEEEDEYSGG LC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards