Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1A)

About Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1A) is a protein from Homo sapiens identified by UniProt accession Q99755, 562 residues long. MolForge cross-references it against 0 known binders and 92 disease associations.

Target properties

Protein name	Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
UniProt accession	Q99755
Gene	PIP5K1A
Organism	Homo sapiens
Length	562 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (8)

DrugCentral-linked approved drugs that act on this protein.

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99755-F1	alphafold	PREDICTED	69.60	—

Amino-acid sequence (562 residues)

MASASSGPSS SVGFSSFDPA VPSCTLSSAA SGIKRPMASE VLEARQDSYI SLVPYASGMP IKKIGHRSVD SSGETTYKKT TSSALKGAIQ LGITHTVGSL STKPERDVLM QDFYVVESIF FPSEGSNLTP AHHYNDFRFK TYAPVAFRYF RELFGIRPDD YLYSLCSEPL IELCSSGASG SLFYVSSDDE FIIKTVQHKE AEFLQKLLPG YYMNLNQNPR TLLPKFYGLY CVQAGGKNIR IVVMNNLLPR SVKMHIKYDL KGSTYKRRAS QKEREKPLPT FKDLDFLQDI PDGLFLDADM YNALCKTLQR DCLVLQSFKI MDYSLLMSIH NIDHAQREPL SSETQYSVDT RRPAPQKALY STAMESIQGE ARRGGTMETD DHMGGIPARN SKGERLLLYI GIIDILQSYR FVKKLEHSWK ALVHDGDTVS VHRPGFYAER FQRFMCNTVF KKIPLKPSPS KKFRSGSSFS RRAGSSGNSC ITYQPSVSGE HKAQVTTKAE VEPGVHLGRP DVLPQTPPLE EISEGSPIPD PSFSPLVGET LQMLTTSTTL EKLEVAESEF TH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards