About Thioredoxin, mitochondrial
Thioredoxin, mitochondrial (TXN2) is a protein
from Homo sapiens identified by UniProt accession
Q99757, 166 residues long.
MolForge cross-references it against 0 known binders and
73 disease associations.
Target properties
| Protein name | Thioredoxin, mitochondrial |
|---|
| UniProt accession | Q99757 |
|---|
| Gene | TXN2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 166 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (73)
Diseases linked to this target (Open Targets).
- combined oxidative phosphorylation defect type 15 · score 0.36
- body height · score 0.07
- isolated spina bifida · score 0.03
- anencephaly 1 · score 0.03
- spina bifida-hypospadias syndrome · score 0.03
- endometriosis · score 0.03
- non-small cell lung carcinoma · score 0.03
- serum non-albumin protein measurement · score 0.02
- Hypoglycemia · score 0.02
- total blood protein measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99757-F1 | alphafold | PREDICTED | 83.98 | — |
Amino-acid sequence (166 residues)
MAQRLLLRRF LASVISRKPS QGQWPPLTSR ALQTPQCSPG GLTVTPNPAR TIYTTRISLT TFNIQDGPDF QDRVVNSETP VVVDFHAQWC GPCKILGPRL EKMVAKQHGK VVMAKVDIDD HTDLAIEYEV SAVPTVLAMK NGDVVDKFVG IKDEDQLEAF LKKLIG
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