About ATP synthase subunit s, mitochondrial
ATP synthase subunit s, mitochondrial (DMAC2L) is a protein
from Homo sapiens identified by UniProt accession
Q99766, 200 residues long.
MolForge cross-references it against 0 known binders and
27 disease associations.
Target properties
| Protein name | ATP synthase subunit s, mitochondrial |
|---|
| UniProt accession | Q99766 |
|---|
| Gene | DMAC2L |
|---|
| Organism | Homo sapiens |
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| Length | 200 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (27)
Diseases linked to this target (Open Targets).
- mean corpuscular hemoglobin concentration · score 0.15
- mean corpuscular volume · score 0.15
- mean corpuscular hemoglobin · score 0.10
- chromosome 22q11.2 microduplication syndrome · score 0.07
- drug use measurement · score 0.07
- Bronchiectasis · score 0.07
- serum metabolite measurement · score 0.06
- ptosis, hereditary congenital, 1 · score 0.06
- jaw-winking syndrome · score 0.06
- Congenital ptosis · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99766-F1 | alphafold | PREDICTED | 91.05 | — |
Amino-acid sequence (200 residues)
MMPFGKISQQ LCGVKKLPWS CDSRYFWGWL NAVFNKVDYD RIRDVGPDRA ASEWLLRCGA MVRYHGQERW QKDYNHLPTG PLDKYKIQAI DATDSCIMSI GFDHMEGLEH VEKIRLCKCH YIEDDCLLRL SQLENLQKTI LEMEIISCGN ITDKGIIALR HLRNLKYLLL SDLPGVREKE NLVQAFKTAL PSLELKLQLK
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