Chemerin-like receptor 1 (CMKLR1)

About Chemerin-like receptor 1

Chemerin-like receptor 1 (CMKLR1) is a protein from Homo sapiens identified by UniProt accession Q99788, 373 residues long. MolForge cross-references it against 0 known binders and 291 disease associations.

Target properties

Protein name	Chemerin-like receptor 1
UniProt accession	Q99788
Gene	CMKLR1
Organism	Homo sapiens
Length	373 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (291)

Diseases linked to this target (Open Targets).

monocyte count · score 0.48
monocyte percentage of leukocytes · score 0.42
high density lipoprotein cholesterol measurement · score 0.35
neutrophil count · score 0.32
lymphocyte:monocyte ratio · score 0.32
body height · score 0.32
balding measurement · score 0.31
blood phosphate measurement · score 0.31
granulocyte percentage of myeloid white cells · score 0.31
PHF-tau measurement · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99788-F1	alphafold	PREDICTED	79.01	—

Amino-acid sequence (373 residues)

MRMEDEDYNT SISYGDEYPD YLDSIVVLED LSPLEARVTR IFLVVVYSIV CFLGILGNGL VIIIATFKMK KTVNMVWFLN LAVADFLFNV FLPIHITYAA MDYHWVFGTA MCKISNFLLI HNMFTSVFLL TIISSDRCIS VLLPVWSQNH RSVRLAYMAC MVIWVLAFFL SSPSLVFRDT ANLHGKISCF NNFSLSTPGS SSWPTHSQMD PVGYSRHMVV TVTRFLCGFL VPVLIITACY LTIVCKLQRN RLAKTKKPFK IIVTIIITFF LCWCPYHTLN LLELHHTAMP GSVFSLGLPL ATALAIANSC MNPILYVFMG QDFKKFKVAL FSRLVNALSE DTGHSSYPSH RSFTKMSSMN ERTSMNERET GML

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards