Cell surface A33 antigen (GPA33)

About Cell surface A33 antigen

Cell surface A33 antigen (GPA33) is a protein from Homo sapiens identified by UniProt accession Q99795, 319 residues long. MolForge cross-references it against 0 known binders and 120 disease associations.

Target properties

Protein name	Cell surface A33 antigen
UniProt accession	Q99795
Gene	GPA33
Organism	Homo sapiens
Length	319 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (120)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.27
prostate carcinoma · score 0.25
leukocyte count · score 0.20
Barrett's esophagus · score 0.09
inflammatory bowel disease · score 0.07
Autosomal recessive early-onset inflammatory bowel disease · score 0.07
inflammatory bowel disease 30 · score 0.06
colitis · score 0.06
Crohn's disease · score 0.06
ulcerative colitis · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99795-F1	alphafold	PREDICTED	85.00	—

Amino-acid sequence (319 residues)

MVGKMWPVLW TLCAVRVTVD AISVETPQDV LRASQGKSVT LPCTYHTSTS SREGLIQWDK LLLTHTERVV IWPFSNKNYI HGELYKNRVS ISNNAEQSDA SITIDQLTMA DNGTYECSVS LMSDLEGNTK SRVRLLVLVP PSKPECGIEG ETIIGNNIQL TCQSKEGSPT PQYSWKRYNI LNQEQPLAQP ASGQPVSLKN ISTDTSGYYI CTSSNEEGTQ FCNITVAVRS PSMNVALYVG IAVGVVAALI IIGIIIYCCC CRGKDDNTED KEDARPNREA YEEPPEQLRE LSREREEEDD YRQEEQRSTG RESPDHLDQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards