About Mitochondrial intermediate peptidase
Mitochondrial intermediate peptidase (MIPEP) is a protein
from Homo sapiens identified by UniProt accession
Q99797, 713 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | Mitochondrial intermediate peptidase |
|---|
| UniProt accession | Q99797 |
|---|
| Gene | MIPEP |
|---|
| Organism | Homo sapiens |
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| Length | 713 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (35)
Diseases linked to this target (Open Targets).
- Mitochondrial disorder due to a defect in mitochondrial protein synthesis · score 0.76
- combined oxidative phosphorylation defect type 11 · score 0.53
- neurodegenerative disease · score 0.52
- cardiomyopathy · score 0.40
- left ventricular noncompaction · score 0.40
- Infantile muscular hypotonia · score 0.40
- genetic disorder · score 0.34
- urate measurement · score 0.29
- bone density · score 0.29
- body height · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99797-F1 | alphafold | PREDICTED | 89.93 | — |
Amino-acid sequence (713 residues)
MLCVGRLGGL GARAAALPPR RAGRGSLEAG IRARRVSTSW SPVGAAFNVK PQGSRLDLFG ERRGLFGVPE LSAPEGFHIA QEKALRKTEL LVDRACSTPP GPQTVLIFDE LSDSLCRVAD LADFVKIAHP EPAFREAAEE ACRSIGTMVE KLNTNVDLYQ SLQKLLADKK LVDSLDPETR RVAELFMFDF EISGIHLDKE KRKRAVDLNV KILDLSSTFL MGTNFPNKIE KHLLPEHIRR NFTSAGDHII IDGLHAESPD DLVREAAYKI FLYPNAGQLK CLEELLSSRD LLAKLVGYST FSHRALQGTI AKNPETVMQF LEKLSDKLSE RTLKDFEMIR GMKMKLNPQN SEVMPWDPPY YSGVIRAERY NIEPSLYCPF FSLGACMEGL NILLNRLLGI SLYAEQPAKG EVWSEDVRKL AVVHESEGLL GYIYCDFFQR ADKPHQDCHF TIRGGRLKED GDYQLPVVVL MLNLPRSSRS SPTLLTPSMM ENLFHEMGHA MHSMLGRTRY QHVTGTRCPT DFAEVPSILM EYFANDYRVV NQFARHYQTG QPLPKNMVSR LCESKKVCAA ADMQLQVFYA TLDQIYHGKH PLRNSTTDIL KETQEKFYGL PYVPNTAWQL RFSHLVGYGA RYYSYLMSRA VASMVWKECF LQDPFNRAAG ERYRREMLAH GGGREPMLMV EGMLQKCPSV DDFVSALVSD LDLDFETFLM DSE
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