About Aconitate hydratase, mitochondrial
Aconitate hydratase, mitochondrial (ACO2) is a protein
from Homo sapiens identified by UniProt accession
Q99798, 780 residues long.
MolForge cross-references it against 0 known binders and
217 disease associations.
Target properties
| Protein name | Aconitate hydratase, mitochondrial |
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| UniProt accession | Q99798 |
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| Gene | ACO2 |
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| Organism | Homo sapiens |
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| Length | 780 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (217)
Diseases linked to this target (Open Targets).
- infantile cerebellar-retinal degeneration · score 0.82
- Autosomal recessive isolated optic atrophy · score 0.60
- Leber hereditary optic neuropathy · score 0.52
- mitochondrial disease · score 0.49
- genetic disorder · score 0.48
- Autosomal dominant optic atrophy, classic type · score 0.46
- acute intermittent porphyria · score 0.34
- isolated macular dystrophy · score 0.27
- body height · score 0.19
- Neurodegeneration · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99798-F1 | alphafold | PREDICTED | 95.43 | — |
Amino-acid sequence (780 residues)
MAPYSLLVTR LQKALGVRQY HVASVLCQRA KVAMSHFEPN EYIHYDLLEK NINIVRKRLN RPLTLSEKIV YGHLDDPASQ EIERGKSYLR LRPDRVAMQD ATAQMAMLQF ISSGLSKVAV PSTIHCDHLI EAQVGGEKDL RRAKDINQEV YNFLATAGAK YGVGFWKPGS GIIHQIILEN YAYPGVLLIG TDSHTPNGGG LGGICIGVGG ADAVDVMAGI PWELKCPKVI GVKLTGSLSG WSSPKDVILK VAGILTVKGG TGAIVEYHGP GVDSISCTGM ATICNMGAEI GATTSVFPYN HRMKKYLSKT GREDIANLAD EFKDHLVPDP GCHYDQLIEI NLSELKPHIN GPFTPDLAHP VAEVGKVAEK EGWPLDIRVG LIGSCTNSSY EDMGRSAAVA KQALAHGLKC KSQFTITPGS EQIRATIERD GYAQILRDLG GIVLANACGP CIGQWDRKDI KKGEKNTIVT SYNRNFTGRN DANPETHAFV TSPEIVTALA IAGTLKFNPE TDYLTGTDGK KFRLEAPDAD ELPKGEFDPG QDTYQHPPKD SSGQHVDVSP TSQRLQLLEP FDKWDGKDLE DLQILIKVKG KCTTDHISAA GPWLKFRGHL DNISNNLLIG AINIENGKAN SVRNAVTQEF GPVPDTARYY KKHGIRWVVI GDENYGEGSS REHAALEPRH LGGRAIITKS FARIHETNLK KQGLLPLTFA DPADYNKIHP VDKLTIQGLK DFTPGKPLKC IIKHPNGTQE TILLNHTFNE TQIEWFRAGS ALNRMKELQQ
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