About Homeobox protein Nkx-3.1
Homeobox protein Nkx-3.1 (NKX3-1) is a protein
from Homo sapiens identified by UniProt accession
Q99801, 234 residues long.
MolForge cross-references it against 0 known binders and
169 disease associations.
Target properties
| Protein name | Homeobox protein Nkx-3.1 |
|---|
| UniProt accession | Q99801 |
|---|
| Gene | NKX3-1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 234 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (169)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- prostate carcinoma · score 0.45
- eosinophil count · score 0.37
- platelet count · score 0.36
- male reproductive organ cancer · score 0.33
- serum albumin measurement · score 0.29
- benign prostatic hyperplasia · score 0.27
- prostate cancer · score 0.26
- mean corpuscular volume · score 0.25
- red blood cell density measurement · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99801-F1 | alphafold | PREDICTED | 65.81 | — |
Amino-acid sequence (234 residues)
MLRVPEPRPG EAKAEGAAPP TPSKPLTSFL IQDILRDGAQ RQGGRTSSQR QRDPEPEPEP EPEGGRSRAG AQNDQLSTGP RAAPEEAETL AETEPERHLG SYLLDSENTS GALPRLPQTP KQPQKRSRAA FSHTQVIELE RKFSHQKYLS APERAHLAKN LKLTETQVKI WFQNRRYKTK RKQLSSELGD LEKHSSLPAL KEEAFSRASL VSVYNSYPYY PYLYCVGSWS PAFW
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