About Transmembrane 9 superfamily member 2
Transmembrane 9 superfamily member 2 (TM9SF2) is a protein
from Homo sapiens identified by UniProt accession
Q99805, 663 residues long.
MolForge cross-references it against 0 known binders and
71 disease associations.
Target properties
| Protein name | Transmembrane 9 superfamily member 2 |
|---|
| UniProt accession | Q99805 |
|---|
| Gene | TM9SF2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 663 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (71)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- lysosomal storage disease · score 0.37
- asthma · score 0.27
- eosinophil count · score 0.25
- systemic lupus erythematosus · score 0.22
- type 1 diabetes mellitus · score 0.20
- serum non-albumin protein measurement · score 0.20
- adult onset asthma · score 0.14
- eosinophil percentage of leukocytes · score 0.14
- periodontal measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99805-F1 | alphafold | PREDICTED | 84.76 | — |
Amino-acid sequence (663 residues)
MSARLPVLSP PRWPRLLLLS LLLLGAVPGP RRSGAFYLPG LAPVNFCDEE KKSDECKAEI ELFVNRLDSV ESVLPYEYTA FDFCQASEGK RPSENLGQVL FGERIEPSPY KFTFNKKETC KLVCTKTYHT EKAEDKQKLE FLKKSMLLNY QHHWIVDNMP VTWCYDVEDG QRFCNPGFPI GCYITDKGHA KDACVISSDF HERDTFYIFN HVDIKIYYHV VETGSMGARL VAAKLEPKSF KHTHIDKPDC SGPPMDISNK ASGEIKIAYT YSVSFEEDDK IRWASRWDYI LESMPHTHIQ WFSIMNSLVI VLFLSGMVAM IMLRTLHKDI ARYNQMDSTE DAQEEFGWKL VHGDIFRPPR KGMLLSVFLG SGTQILIMTF VTLFFACLGF LSPANRGALM TCAVVLWVLL GTPAGYVAAR FYKSFGGEKW KTNVLLTSFL CPGIVFADFF IMNLILWGEG SSAAIPFGTL VAILALWFCI SVPLTFIGAY FGFKKNAIEH PVRTNQIPRQ IPEQSFYTKP LPGIIMGGIL PFGCIFIQLF FILNSIWSHQ MYYMFGFLFL VFIILVITCS EATILLCYFH LCAEDYHWQW RSFLTSGFTA VYFLIYAVHY FFSKLQITGT ASTILYFGYT MIMVLIFFLF TGTIGFFACF WFVTKIYSVV KVD
Explore Transmembrane 9 superfamily member 2 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets