About Equilibrative nucleoside transporter 1
Equilibrative nucleoside transporter 1 (SLC29A1) is a protein
from Homo sapiens identified by UniProt accession
Q99808, 456 residues long.
MolForge cross-references it against 0 known binders and
235 disease associations.
Target properties
| Protein name | Equilibrative nucleoside transporter 1 |
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| UniProt accession | Q99808 |
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| Gene | SLC29A1 |
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| Organism | Homo sapiens |
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| Length | 456 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (235)
Diseases linked to this target (Open Targets).
- coronary artery disease · score 0.55
- stroke · score 0.55
- Myocardial Ischemia · score 0.47
- diabetes mellitus · score 0.37
- Takotsubo cardiomyopathy · score 0.37
- ischemia reperfusion injury · score 0.37
- Recurrent thrombophlebitis · score 0.37
- serum lipopolysaccharide activity · score 0.37
- bipolar disorder · score 0.37
- fetal erythroblastosis · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99808-F1 | alphafold | PREDICTED | 87.36 | — |
Amino-acid sequence (456 residues)
MTTSHQPQDR YKAVWLIFFM LGLGTLLPWN FFMTATQYFT NRLDMSQNVS LVTAELSKDA QASAAPAAPL PERNSLSAIF NNVMTLCAML PLLLFTYLNS FLHQRIPQSV RILGSLVAIL LVFLITAILV KVQLDALPFF VITMIKIVLI NSFGAILQGS LFGLAGLLPA SYTAPIMSGQ GLAGFFASVA MICAIASGSE LSESAFGYFI TACAVIILTI ICYLGLPRLE FYRYYQQLKL EGPGEQETKL DLISKGEEPR AGKEESGVSV SNSQPTNESH SIKAILKNIS VLAFSVCFIF TITIGMFPAV TVEVKSSIAG SSTWERYFIP VSCFLTFNIF DWLGRSLTAV FMWPGKDSRW LPSLVLARLV FVPLLLLCNI KPRRYLTVVF EHDAWFIFFM AAFAFSNGYL ASLCMCFGPK KVKPAEAETA GAIMAFFLCL GLALGAVFSF LFRAIV
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