Tumor susceptibility gene 101 protein (TSG101)

About Tumor susceptibility gene 101 protein

Tumor susceptibility gene 101 protein (TSG101) is a protein from Homo sapiens identified by UniProt accession Q99816, 390 residues long. MolForge cross-references it against 0 known binders and 151 disease associations.

Target properties

Protein name	Tumor susceptibility gene 101 protein
UniProt accession	Q99816
Gene	TSG101
Organism	Homo sapiens
Length	390 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (151)

Diseases linked to this target (Open Targets).

HIV infection · score 0.53
viral disease · score 0.47
neurodegenerative disease · score 0.34
hepatocellular carcinoma · score 0.10
neoplasm · score 0.08
renal cell carcinoma · score 0.07
infection · score 0.07
infect · score 0.07
cancer · score 0.06
breast cancer · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99816-F1	alphafold	PREDICTED	82.96	—

Amino-acid sequence (390 residues)

MAVSESQLKK MVSKYKYRDL TVRETVNVIT LYKDLKPVLD SYVFNDGSSR ELMNLTGTIP VPYRGNTYNI PICLWLLDTY PYNPPICFVK PTSSMTIKTG KHVDANGKIY LPYLHEWKHP QSDLLGLIQV MIVVFGDEPP VFSRPISASY PPYQATGPPN TSYMPGMPGG ISPYPSGYPP NPSGYPGCPY PPGGPYPATT SSQYPSQPPV TTVGPSRDGT ISEDTIRASL ISAVSDKLRW RMKEEMDRAQ AELNALKRTE EDLKKGHQKL EEMVTRLDQE VAEVDKNIEL LKKKDEELSS ALEKMENQSE NNDIDEVIIP TAPLYKQILN LYAEENAIED TIFYLGEALR RGVIDLDVFL KHVRLLSRKQ FQLRALMQKA RKTAGLSDLY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards