About Rho GDP-dissociation inhibitor 3
Rho GDP-dissociation inhibitor 3 (ARHGDIG) is a protein
from Homo sapiens identified by UniProt accession
Q99819, 225 residues long.
MolForge cross-references it against 0 known binders and
44 disease associations.
Target properties
| Protein name | Rho GDP-dissociation inhibitor 3 |
|---|
| UniProt accession | Q99819 |
|---|
| Gene | ARHGDIG |
|---|
| Organism | Homo sapiens |
|---|
| Length | 225 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (44)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.12
- mean corpuscular hemoglobin concentration · score 0.12
- mean corpuscular hemoglobin · score 0.08
- erythrocyte count · score 0.07
- HbA1c measurement · score 0.07
- interstitial lung disease · score 0.06
- body mass index · score 0.06
- body fat percentage · score 0.06
- body height · score 0.05
- cardiovascular disease · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99819-F1 | alphafold | PREDICTED | 84.01 | — |
Amino-acid sequence (225 residues)
MLGLDACELG AQLLELLRLA LCARVLLADK EGGPPAVDEV LDEAVPEYRA PGRKSLLEIR QLDPDDRSLA KYKRVLLGPL PPAVDPSLPN VQVTRLTLLS EQAPGPVVMD LTGDLAVLKD QVFVLKEGVD YRVKISFKVH REIVSGLKCL HHTYRRGLRV DKTVYMVGSY GPSAQEYEFV TPVEEAPRGA LVRGPYLVVS LFTDDDRTHH LSWEWGLCIC QDWKD
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