Calcium and integrin-binding protein 1 (CIB1)

About Calcium and integrin-binding protein 1

Calcium and integrin-binding protein 1 (CIB1) is a protein from Homo sapiens identified by UniProt accession Q99828, 191 residues long. MolForge cross-references it against 0 known binders and 264 disease associations.

Target properties

Protein name	Calcium and integrin-binding protein 1
UniProt accession	Q99828
Gene	CIB1
Organism	Homo sapiens
Length	191 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (264)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.52
epidermodysplasia verruciformis · score 0.50
serum gamma-glutamyl transferase measurement · score 0.18
coronary artery disease · score 0.14
neoplasm · score 0.10
azoospermia · score 0.09
partial chromosome Y deletion · score 0.09
Male infertility with spermatogenesis disorder due to single gene mutation · score 0.09
triple-negative breast cancer · score 0.08
male infertility with teratozoospermia due to single gene mutation · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99828-F1	alphafold	PREDICTED	75.74	—

Amino-acid sequence (191 residues)

MGGSGSRLSK ELLAEYQDLT FLTKQEILLA HRRFCELLPQ EQRSVESSLR AQVPFEQILS LPELKANPFK ERICRVFSTS PAKDSLSFED FLDLLSVFSD TATPDIKSHY AFRIFDFDDD GTLNREDLSR LVNCLTGEGE DTRLSASEMK QLIDNILEES DIDRDGTINL SEFQHVISRS PDFASSFKIV L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards